What is CBC, Exactly?

CBC (Cannabichromene)

CBC, also known as Cannabichrome or Cannabichromene, is a major phytocannabinoid like THC and CBD that was first discovered by the “Father of Cannabis” Professor Raphael Mechoulam in the mid-1960s (1). CBC is one of the most prevalent cannabinoids found in flowers - usually in concentrations less than 1% per gram but present in almost every variety of cannabis and hemp. 

CBC is created in the plant in a similar way that THC and CBD are created. First, it begins with the mother cannabinoid CBGA or Cannabigerolic Acid. The plant produces an enzyme called CBCA synthase which converts CBGA into CBCA, much like CBD and THC synthase create THCA and CBDA from CBGa as well. Then, when CBCA is heated (decarboxylated) it further degrades into active CBC (2). 

How is CBC Different From THC or CBD?

CBC does not act in the same way that THC or CBD does on our endocannabinoid system. It has weak activity at our CB2 receptors, lending some aid to fight inflammation and calm gastrointestinal issues, but it does not bind effectively with our CB1 receptors (3). Therefore, CBC does not produce a psychoactive effect. Instead, CBC acts on our TRPV1 and TRPA1 receptors. These channels are responsible for our bodies noticing temperature changes, pain signaling, and many more functions. CBC also helps slow the breakdown of cannabinoids by these TRPV/TRPA receptors, which can prolong or enhance the effects of other cannabinoids like THC (1).

This cannabinoid has been studied for its anti-depressant, analgesic, and anti-inflammatory properties (4). Using CBC is as easy as utilizing other cannabinoids, it can be used in edibles, vapes, and topicals and usually comes in a golden liquid distillate form. Usually only a small amount of CBC is needed in comparison to other cannabinoids like THC or CBD when incorporated into blends. CBC works as a solvent for other cannabinoids, so it will help with mixing thicker cannabinoids like Delta 8 distillate or CBN isolate, thinning blends down to a more workable consistency.

CBC has also been studied much like other cannabinoids for its anti-fungal, and antibacterial properties. It has been described as a strong antibacterial, outperforming the drug phenylbutazone in one test, and proved to have mild anti-fungal properties when tested against yeast-like fungus and other types of fungi (5).

Bottom Line

This major cannabinoid highlights the magic of the Entourage Effect; phytocannabinoids and other compounds working together to create a much stronger and complex experience when consuming full spectrum products. With its ability to work synergistically with cannabinoids like THC and CBD, and its direct effects on our TRP ion channels, this relatively low-yielding cannabinoid may be one of the biggest contributors to the Entourage Effect of all.

Sources

1 - https://www.cnbs.org/cannabinoids/cbc-cannabichromene/

2 - https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5812543/

3 - https://pubmed.ncbi.nlm.nih.gov/31368508/

4 - https://pubmed.ncbi.nlm.nih.gov/20332000/

5 - https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3417459/

6 - https://pubmed.ncbi.nlm.nih.gov/7298870/

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