THCp Vs. THCo: What are the big differences?
The cannabinoid marketplace can be confusing, with so many acronyms that it almost takes a degree in chemistry to know what it all means. However, it is essential to differentiate between them to understand their effects and benefits fully. This article aims to demonstrate the difference between THCo-acetate (THCO) and Δ9-Tetrahydrocannabiphorol (THCP), two of the most popular cannabinoids, and help you understand how their chemical structure affects their effects and bioavailability, and how they interact with our endocannabinoid receptors.
THCP and THCO: A Chemical Comparison
The cannabis plant makes many varieties of THC, and many of these homologs have lots of claims. However, THCP and THCO stand out from the rest due to their unique chemical structures. THCP, which stands for Δ9-Tetrahydrocannabiphorol, is the most powerful phytocannabinoid yet to be discovered in cannabis. It has two more carbons added on to the “tail” than THC, causing different effects. Conversely, THCO is a prodrug version of THC, which means that an acetate is added to THC, dramatically increasing its bioavailability.
THCP: The Most Powerful Phytocannabinoid Yet Discovered
Since its discovery a few years ago, THCP has been found to occur naturally in small quantities in 13 of 14 strains, although in smaller amounts. Its longer tail allows it to bind to the cb1 receptor much stronger than other cannabinoids. Although a slight chemical difference, its interactions at our endocannabinoid receptors are of great interest. Empirical and experimental studies have shown THCP to be substantially stronger than its shorter-tailed homolog THC. In most cases, THCP was diluted typically to less than 20% of the mixture. Most users describe it as being stronger than D9 THC at this diluted amount, and its duration is substantially longer than THC, with effects lasting 12-24 hours.
THCO: A Prodrug Version of THC
THCO acetate is a prodrug version of THC, with an acetate added to THC. The added acetyl group dramatically increases its bioavailability, allowing for easier absorption by our bodies. When vaped, THCO has a delay in effects of anywhere from 15-30 minutes. The acetylation of any cannabinoid can turn it into a prodrug version, including THCP.
THCO vs. THCP: Which One is Stronger and More Long-Lasting?
THCP is significantly stronger than THC, especially in terms of duration. It has not been reported to be psychedelic, nor is it 33 times stronger than THC, as some claim it to be. Empirically, THCP is significantly stronger than THC, and most users describe its effects as being stronger than D9 THC.
THCP is still a relatively new cannabinoid and more research is needed to fully understand its effects and potential benefits. However, initial studies have shown promising results, particularly in regards to its potential as a pain reliever, anti-inflammatory, and antipsychotic. It is also worth noting that THCP is found in much smaller quantities in cannabis than THC, so it is unlikely to become a major player in the cannabis market anytime soon.
THCO, on the other hand, has been around for much longer and is more commonly used in pharmaceuticals. While it may not be as potent as THCP, it is still a useful tool for increasing the bioavailability of THC and creating new forms of cannabis products.
In conclusion, while both THCP and THCO are modifications of THC, they have distinct differences and potential benefits. THCP is the most powerful phytocannabinoid discovered so far, with a longer carbon tail that allows it to bind to the CB1 receptor more strongly than other cannabinoids. THCO, on the other hand, is a prodrug version of THC that increases its bioavailability and has been used in pharmaceuticals for decades. As always, it is important to consult with a healthcare professional before trying any new cannabis products.