The Difference Between Delta 8, Delta 9 and Delta 10
Delta-8, Delta-9, and Delta-10 THC are three different isomers of tetrahydrocannabinol that are found naturally in cannabis plants. Despite their similarity in chemical structure, each isomer has a unique chemical profile that impacts its affinity to the CB1 receptor and its effects on the body. In this article, we will explore the differences between Delta-8, Delta-9, and Delta-10 THC and answer some of the most frequently asked questions about these cannabinoids.
Delta 8, Delta 9, and Delta 10: A Brief Introduction
Delta-9-tetrahydrocannabinol (Delta 9 THC) is the most well-known cannabinoid and the main psychoactive component of the cannabis plant. However, after the 2018 Farm Bill legalized the production of hemp, researchers started exploring other cannabinoids found in the plant. Delta-8-tetrahydrocannabinol (Delta 8 THC) and delta-10-tetrahydrocannabinol (Delta 10 THC) are two isomers of Delta 9 THC that have similar effects but different chemical structures. In this article, we will discuss the main differences between Delta 8 vs Delta 9 vs Delta 10 and explore the effects of each.
The Chemistry of Delta 8, Delta 9, and Delta 10 THC
As shown in Figure 1, Delta 8, Delta 9, and Delta 10 THC have a very similar chemical structure as well as the same chemical formula. They are isomers of each other, and the only difference between them is the position of the double bond. This position of the carbon-carbon double bond affects the binding affinity to the CB1 receptor. Delta 8 THC has a lower affinity than Delta 9 THC, while Delta 10 THC is not presently known but is thought to lay somewhere in between Delta 9 and Delta 8 THC. Due to the relative newness of Delta 10 THC, there has not been abundant research on it, but we know from one paper that Delta 9 THC has a range of reported Ki values for CB1 as 5.05–80.3 (nmol l-1) while Delta 8 THC had a range of 44–47.6 (nmol l-1).
The Main Differences Between Delta 8 vs Delta 9 vs Delta 10
While Delta 8, Delta 9, and Delta 10 THC have similar effects, there are some differences between them. Delta 8 THC is known to have a lower affinity than Delta 9 THC, while Delta 10 THC is not presently known but is thought to lay somewhere in between Delta 9 and Delta 8 THC. Some users of Delta 8 THC notice that it seems to help with pain a little more than Delta 9 THC. Insomnia is another common ailment that people have traditionally reached out to Delta 9 THC for relief. In this case, many users have noted Delta 10 THC to be more energetic, which may negate the ability to fall asleep. One paper published showed that Delta 8 THC had a demonstrated increase in food consumption, which could help those suffering from low appetite.
Effects on the Body: Similarities and Differences
THC is known to help with pain and can bind to the receptor CB2 in addition to CB1, which supports its effectiveness with pain. Delta 8 and Delta 10 THC are similar to Delta 9 THC, and users can expect somewhat similar effects, but possibly slightly less so. For instance, some users of Delta 8 THC notice that it seems to help with pain a little more than Delta 9. Insomnia is another common ailment that people have traditionally reached out to Delta 9 THC for relief. In this case
In summary, Delta 8, Delta 9, and Delta 10 are all isomers of THC, each with slightly different chemical structures that affect their binding affinity to the CB1 receptor and potentially different effects on the body. While Delta 9 THC is the most well-known and studied, Delta 8 and Delta 10 THC are becoming increasingly popular for their potential therapeutic benefits. It’s important to note that the safety and effectiveness of these cannabinoids is still being studied and more research is needed to fully understand their effects on the body. If you’re interested in trying Delta 8, Delta 9, or Delta 10 THC, make sure to purchase from a reputable vendor and consult with a healthcare professional beforehand.