CBD or cannabidiol is a non-psychoactive compound found in non-psychotropic “hemp” varieties of Cannabis Sativa. The major metabolites cannabidiol (CBD) and cannabidiolic acid (CBDA) are produced in abundance in these plants, whereas traditional psychotropic “marijuana” plants have low concentrations of CBD.
CBD and Anxiety: How Does It Work?
Research has shown that CBD can help manage symptoms of anxiety by interacting with the human endocannabinoid receptors CB1 and CB2. These receptors alter serotonin signals, a natural neurotransmitter also known as the “feel-good hormone,” which plays a crucial role in mental health issues such as depression and anxiety. Medical treatment for low serotonin is typically through the use of a selective serotonin reuptake inhibitor (SSRI), which can have unwanted side effects or may not work well for some individuals.
CBD has demonstrated therapeutic efficacy in models of anxiety and stress, reducing both behavioral and physiological measures of stress and anxiety. It can help in the treatment of symptoms from generalized anxiety disorder (GAD) and social anxiety disorder.
In addition to endocannabinoid receptors activity, CBD can drive its neuroprotective, anti-depressive, and anti-anxiety benefits through its activity at 5-HT1A receptors. However, the certain mechanism of action in which CBD decreases anxiety is still unclear. Different studies have suggested different dosages, ranging from 10 mg/kg to 600 mg, depending on the study’s conditions.
CBD does not cause intoxicating effects as it differs significantly enough from THC. It can help in various conditions such as epilepsy, nausea, and pain relief, and has shown potent antioxidant and neuroprotective effects. CBD has been found to be cytotoxic in many tumor cell types while still exhibiting cytoprotective effects on normal cells and neurons. Also, in oncology therapy, CBD has demonstrated the potential to enhance gamma radiation sensitivity in human glioblastoma cells.
CBD affects humans through the endocannabinoid system (ECS), a complex endogenous signal network that has multiple functions. The two main receptor types in this system are called CB1 and CB2. Our bodies make cannabinoids called endocannabinoids, which CBD mimics, providing its therapeutic potential.
How is CBD Consumed?
CBD is available in various products and forms such as CBD distillate, a thick oil commonly used in vaporizers, dabbing, or mixed into tinctures, and CBD isolate, a more purified form commonly produced. It is essential to consult a physician before making any medication changes.
In summary, CBD can help manage symptoms of anxiety, is non-intoxicating, has therapeutic efficacy in various conditions, and mimics our bodies’ natural cannabinoids, providing its therapeutic potential through the ECS.
